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--WEDNESDAY - 1/19/22 - ASBURY TAKE-OUT MEAL - $12 - Call 585-237-5262 -- Stay in Your Car for Pickup -- Seared Stuffed Chicken With Cracker Crumb Stuffing, Twice Baked Potato, Mixed Veggies, Dinner Roll, Mixed Berry Cobbler (Eat-In also open).
--FIRST MEETING OF THE SLI TRUSTEES IN 2022 will be the third Saturday in April--the 24th, 10 am, location TBA.

Friday, August 14, 2020

The Treatment That Could Crush Covid Wall Street Journal

Early trials show signaling cells eliminate the virus, 
calm the immune response and repair tissue damage. 
By Kevin Kimberlin Aug. 13, 2020 7:18 pm ET 
 
Submitted to the Silver Lake Daily Newsletter
by Dr. Robert Cook, Silver Lake Institute, Silver Lake, NY

ILLUSTRATION: MARTIN KOZLOWSKI

More than 500 clinical trials are under way world-wide in the race to find an effective treatment for Covid-19. Everybody wants it; nobody has it—yet. But one of the most promising therapies for Covid-19 patients uses “medicinal signaling cells,” or MSCs, which are found on blood vessels throughout the body.

In preliminary studies, these cells cut the death rate significantly, particularly in the sickest patients. With a powerful 1-2-3 punch, these cells eliminate the virus, calm the immune overreaction known as a cytokine storm, and repair damaged lung tissue—a combination offered by no other drug. This type of regenerative medicine could be as revolutionary as Jonas Salk’s polio vaccine.

OPINION: POTOMAC WATCH
00:00 / 23:18

In one pilot study in March, doctors at Mount Sinai Hospital in New York treated a dozen severely ill Covid-19 patients on ventilators with MSCs. Two infusions modulated their hyperactive immune systems, and 83% of those patients survived. With such promising results, the team at Mount Sinai and the supplier of the cells, Mesoblast Ltd., won Food and Drug Administration clearance and National Institutes of Health funding to conduct a randomized trial on 300 patients. The first patients in the trial received the treatment in early May.

A July 10 article in the Lancet reported on 13 critically ill Covid-19 patients also treated with MSCs. Eleven of the 13 patients lived—an 85% survival rate, which mirrors the results from Mount Sinai. The number of virus-fighting T-cells rose even as inflammation fell, suggesting that these cells can control the immune response as needed. In addition, chest X-rays showed that the drug repaired lung tissue, in some cases within 48 hours.

Healing tissue is essential because the cytokine battle with the Covid-19 virus is so vicious that it punches holes in the delicate lung membranes, allowing the virus to flood into the bloodstream and body cavities. These holes must be repaired, as virus leaks create some of the complications not usually associated with respiratory infections—blood clotting, heart attacks, stroke and multiple organ failure, which cause about 40% of Covid-19-related deaths. Blood-vessel density, and thereby the number of MSCs, decreases as we age, gain weight or develop diseases, which may explain why the elderly and those with chronic health conditions are faring worst.

In other words, this disease appears to be both a respiratory and a vascular infection. That is why the ability to fight infection, control the immune response and repair damaged tissue is such a valuable combination.

How can one drug do all this? MSCs were first identified and named by Prof. Arnold Caplan and colleagues at Case Western Reserve University in Ohio nearly 30 years ago. To translate this discovery into therapies, Mr. Caplan and I in 1993 launched Osiris Therapeutics, Inc. which developed this MSC into the world’s first approved systemically delivered cell therapy. During early years of scientific inquiry, Mr. Caplan and colleagues discovered that MSCs monitor and protect virtually every vessel in our bodies—the 60,000 miles of vessels that transport oxygen, nutrition and waste to and from every one of our cells.

When a MSC detects an infection or an injury to those vessels, it transforms into a factory to recruit and pump out immune-modulating and vessel-repair agents. These cells ameliorate crippling and deadly conditions when traditional chemical or biochemical drugs fail. The number of potential uses is enormous. MSCs are being tested on more than 900 different human ailments. Mr. Caplan describes these cells not as a “wonder drug,” but as a wonder drugstore.

Consider the results from trials conducted by Mesoblast on graft-versus-host Disease. Children with this horrible affliction suffer such a violent immune reaction that the skin and the lining of their intestines peel off. Up to 80% of children die if steroids don’t stop the inflammation. But in one trial, 160 of 239 patients (67%) who didn’t respond to steroids and other treatments survived after infusion with MSCs. Their cytokine storm disappeared. Injured tissues normalized. Based on these results, the FDA agreed to expedite its review and grant a decision by Sept. 30.

This is exactly the type of cell being tested for Covid-19 in the May trial. If the cells perform as they did at Mount Sinai in March and elsewhere, the results should be available before the end of September. A positive finding could help those most at risk of the disease’s worst effects. But the medical community and wider public are largely unaware of the potential for using MSCs to treat Covid.

Amid so much darkness, MSCs are a ray of hope—not only for the most desperate coronavirus patients, but all of us ready to end the pandemic and discover new ways to fix the body’s broken systems.

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W. PETE MAIRS

W. PETE MAIRS
Walter D. “Pete” Mairs, 81, died peacefully on July 23, 2021. Born in Avon, N.Y., on Sept. 3, 1939, Pete was a longtime resident of Geneva, N.Y., and these past many years in Buffalo, N.Y., as well as his beloved Silver Lake. Pete is survived by his wife, Linda Bergstrom Mairs, a loving and true companion; children, Mimi C. Mairs, Jonathan B. Mairs; sisters, June Huff, Helen Dole; brother, Thomas Mairs; stepchildren, Daniel Brinkworth, Jennie Ramsey; sister-in-law, Anne Bergstrom, eight beautiful grandchildren, and nieces and nephews. A service and celebration of life is planned for the fall when all can share the joy of Pete’s life together. Arrangements by Stephenson – Dougherty Funeral Home, Avon, N.Y.

Editor's Note: It was a privilege knowing and working with Pete Mairs during his presidency of the Silver Lake Institute. He was a kind and gentle man, but also firm in his leadership. I served as Treasurer and Chaplain of SLI during those years and I could always depend on Pete's presence in the worship service. He was a man of faith and a gem of a human being. May he rest in God's care.

GERALD C. SAHRLE

GERALD C. SAHRLE
Gerald C. Sahrle, 80, of Perry, passed away on Sunday, Oct. 24, 2021, at Strong Memorial Hospital in Rochester. He was born on Oct. 10, 1941, in Wayland, N.Y., to the late Charles A. and Helen I. (Blowers) Sahrle. Gerry was a line foreman for 32 1/2 years for NYSE&G, working out of the Perry and Hamburg locations, and was a Town of Perry Councilman. He was a member of the Free and Accepted Masons of the Constellation Lodge -404 in Perry. He was an avid fisherman, hunter and woodworker. He is survived by his wife, Valary A. (Conley) Sahrle; 1 son, Gerald (Pamela) Sahrle II of Silver Springs; 2 sisters, Millie Edmond of Greece, Bonnie Fink of Winston-Salem, N.C., 3 brothers, Ronald (Linda) Sahrle of Dansville, Robert (Susan) Sahrle of Springwater, Kenneth Sahrle of Dansville; 5 grandchildren, Bradley Musscarella, Stone and Winston Sahrle, Conley and Cooper Gayton; along with many nieces, nephews and friends. Along with his parents, he is preceded in death by a brother, Thomas Sahrle, who passed away in 2012. Services will be held at the convenience of the family. Gerry will be laid to rest in West Perry Cemetery. Memorial contributions may be made to the Perry Center Fire Department, P.O. Box 204, Perry, NY 14530. For more information, please call (585) 237-2626 or to leave a message of condolence, visit www.eatonwatsonfuneralhome.com. Arrangements completed by Eaton-Watson Funeral Home, LLC. 98 North Main Street, Perry, NY 14530.

Editor's Note: Gerald and Valarie could always be seen in the family pew with Pamela, Stone and Winston at Perry First United Methodist Church and continue to be loved. Gerry will be sorely missed. Both were supporters of the Arts at the Silver Lake Institute and Valarie was active in painting and participating in the Annual Show in August. Valarie's presence was always valued and appreciated.

KATHARINE E. PRACZKAJLO ("Kathy P.")

KATHARINE E. PRACZKAJLO ("Kathy P.")
"Kathy P." passed November 8, 2021, of Hamburg and Boston, NY. Beloved daughter of Joseph and Barbara Michalak; loving sister of Daniel Michalak; devoted wife of the late Jeffrey Praczkajlo; cherished mother of Jennifer (Shawn) Jump; loving babcia of Lily Jump; also survived by many beloved family members and friends who became her family. A Celebration of Life will be held at a later date.

Editor's Note: "Kathy P." as she was better known to us at Silver Lake was an annual summer visitor for most of the last number of years at the invitation of Silver Laker Julia Hoffner. She stayed at the Hoffner Cottage, and became known as both the fun visitor with the vivacious smile to the neighbors at the intersection of Haven Ave. and the Ames Walkway. Kathy P. and Julie could be seen walking and talking between the cottage and the Hoffner boathouse where they could be close to the water. She was also occasionally seen at the Saturday morning breakfasts at Stoody Hall. Her stay was anywhere between 4 days and a week where she had the opportunity to develop a love for Silver Lake. She was not yet eligible for retirement when late last week she developed "a cold" and had to remain home from her job. She did not update her condition over the weekend so the local police made a wellness visit and found her deceased on Monday. She was one of those many people who found Silver Lake and friendship for brief respites where she also found new strength and energy to return to work. She is being particularly mourned by those in the Haven/Ames neighborhood. She will be memorialized next summer at the annual Celebration of Life Memorial Service at Epworth Hall.

BRENDA J. PADDOCK

BRENDA J. PADDOCK
Brenda Joan Paddock, 82, of Perry, born April 15, 1939, now resides in heaven with her Lord and Savior Jesus Christ. Brenda met Jesus as her Savior in 1965. She met him in person on Nov. 14, 2021. She had a beautiful homecoming with music, singing and praying, leading her into Glory. Her last words were “I am well, I am well.”

Brenda’s greatest loves were her family and friends. Brenda had five children with her husband Roger: Don and Daelene Paddock of Florida, Jody and Tim Von Sanden of Pavilion, Bradley and Jeanie Paddock of Warsaw, Jennifer and Paul Guy of Massachusetts, and Nathan and Jill Paddock of Perry.

Brenda dearly loved her grandchildren: Jessica Morillo, Nikki and Clint O’Brien, Luke Paddock, Paul Paddock, Ian and Brooklyn Paddock, Joe and Louana Paddock, Burke and Megan Paddock, Aaron Paddock, Ellen Paddock, Andrew Paddock, Rachael Paddock, Abigail Paddock, Erik and Cassandra Von Sanden, Jacquelyn and Michael Jones, Tim Von Sanden, Brandon and Brandee Paddock, Jamey and Laura Paddock, Peter and Kara Guy, Candy and Jay Waitkevich, Marlo and Ryan Bolger and Jenna and Rory Peterson.

Brenda was blessed and loved her great grandchildren: Chloe, Olivia and Nicholas Von Sanden, Joshua and Jaxon Morillo, Jameson and Cassandra O’Brien, Atlas Paddock, Noah and Ezra Jones, Colton, Brantley and Charlotte Guy, Cameron Waitkevich, Amelia Bolger and Brennen Leonard.

Brenda is also survived by her brother and sister in laws; Frank and Emma Paddock, Viva and Jim Phillips-Richardson and Kurt and Lynn Paddock.

Brenda first started working as a secretary at Perry Central School. She then assisted her husband building Paddock’s Breeding Service. Roger and Brenda together built and ran the Sandsabarn teenage nightclub. Brenda was owner and operator of Serendipity Travel. Brenda’s pleasures included playing organ and piano. She played at a number of area churches along with performing for her loved ones. UPDATED -- Brenda also played with conviction at both indoor and outdoor services at the Silver Lake Institute where her grandson, Luke, sang at Epworth Hall on several occasions and was appreciated by all who heard his inspiring voice.

Brenda was preceded in death by her parents Noble and Freda Buckland, her husband Roger and son Bradley.

A Committal service at West Perry Cemetery will be held tomorrow, Wednesday, November 17 at 11 a.m., followed by a Celebration of Life at LaGrange Baptist Church at 4 p.m.

Memorial donations may be made in Brenda’s honor to the LaGrange Baptist Church 7092 LaGrange Rd. Perry, NY 14530 or to the First Congregational Church P.O. Box 156 Perry, NY 14530. Arrangements completed by Eaton-Watson Funeral Home, LLC. 98 N. Main St., Perry, N.Y. 14530. For more information or to sign the online guest registry please visit www.eatonwatsonfuneralhome.com.

AUGUST 4-7, 2022

AUGUST 4-7, 2022
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